I started taking Naproxen yesterday afternoon and if the last 18 hours are indicative I am ready to call it a wonder drug. My knees and ankles hurt much less, so far: I don't have nearly the pain I had, say, yesterday morning in rising out of chairs. The next big test will come soon: negotiating stairs. I'm going to have to read up on the effects of taking it long-term. So far, though, so good!